GlycoGAIT (Glycosylation and Gut Associated Immune Tolerance)
GlycoGAIT Aim Current Status Features
Aim :

To create an interactive web database to access unique data resource comprising integrated molecular network data linking human gastrointestinal tissues, gut immune system and the gut microbiome. This will enable to identify glycosylation relevance in gut barrier in response to commensal and pathogenic bacteria for modulating the gut immune tolerance. Additionally, by leveraging diverse omics data focusing on glycome biology, under diverse gastrointestinal immune dysfunction background, we aim to identify core mechanisms underlying these diseases that will aid novel therapies, diagnostic markers which will significantly address the large set of unmet needs in the treatment of these global diseases that are assuming epidemic proportions.

Current Status :

The project is aimed to be completed in three different versions. In the current version 1 of the database, we provided a user friendly web interface to systematically analyze the unique list of glycosylation process related genes (glycogenes) for identifying gene expression changes under gastrointestinal immune dysfunction background. Currently the database comprises of 548 well characterized genes belonging to glycogenes and lectins along with selected gene expression data obtained from human biopsy samples under both H. pylori infection and inflammatory bowel disease (IBD) condition available in the public gene expression database (GEO). In version 2 and 3 we aim to create an integrated molecular network data linking human gastrointestinal tissues, gut immune system and the gut microbiome providing a unique source to identify glycosylation relevance in gut barrier in response to commensal and pathogenic bacteria for modulating the gut immune tolerance.

Features :